liposomal glutathione

A Complete Guide to Liposomal Glutathione

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Last modified on March 30th, 2022

Liposomal glutathione can be one of the most powerful supplements available, and added to your routine can have tremendous health benefits.

Key Takeaways

  • Glutathione is in our cells and it’s made from three amino acids—cysteine, glutamate, and glycine
  • Glutathione is a key antioxidant in your body that protects your cells from damage
  • Glutathione levels decline as we age and low levels are linked to poor health
  • Liposomal glutathione is a way to supplement this detoxifier and get the most absorbability

What Is Liposomal Glutathione?

Glutathione is often called one of the body’s most powerful detoxifier, and it supports immune function as well as neutralizing free radicals.

Glutathione contains three amino acids:

  • Cysteine
  • Glutamate
  • Glycine

Glutathione helps combat the damaging free radicals through your body and help support your body’s natural detoxification as it removes pollutants, drugs, and chemicals.

Because glutathione is within every cell of our body, it’s the most important antioxidant we have. Its location within our cells makes it ideal for the neutralizing of free radicals.

Research has found that if you look at patients in hospitals who are critically ill, including with cancer, they have depleted glutathione levels.

Some of the functions of glutathione include:

  • Making DNA
  • Supporting the optimal functioning of the immune system
  • Breaking down free radicals
  • Helping enzymes function
  • Regeneration of vitamins C and E
  • Removing mercury from the brain
  • Formation of sperm cells
  • Helping the gallbladder and liver deal with fats
  • Assisting apoptosis, which is regular cell death

As you get older, it’s likely your body can’t make as much glutathione. Glutathione levels often decline with conditions including not just cancer but also Type 2 diabetes, hepatitis, Parkinson’s disease, and HIV/AIDS.

If you want to supplement with glutathione, it can be challenging.

First, many studies have shown that taking glutathione orally means it won’t reach different parts of your body because your stomach enzymes break it down too quickly.

There a few options.

You can take liposomal glutathione. You can also have glutathione injected intravenously.

Certain supplements are precursors of glutathione, which you can take to help boost your body’s natural production.

These glutathione-boosting supplements include:

  • Curcumin
  • Selenium
  • Vitamin C
  • Vitamin E
  • Silymarin
  • N-acetylcysteine

Some foods that are high in amino acids may give you a bit of glutathione, but our bodies don’t absorb food sources that well.

Food sources include unprocessed meat, broccoli, avocados, and spinach.

The Benefits of Glutathione

The following are some of the possible benefits of glutathione:

Antioxidant Properties

Glutathione can neutralize free radicals. Free radicals contribute to many diseases as well as aging. Because glutathione is in every cell of our body, it’s an especially powerful antioxidant.

Free radicals can cause something called oxidative stress, and that process is linked to cardiovascular disease, neurodegenerative disease, accelerated aging, autoimmune disorders and cancer.

Research has shown glutathione may have a role in preventing cancer’s progression. At the same time, glutathione may make tumors less sensitive to chemotherapy, so speak with your doctor before taking any supplement when you’re receiving cancer treatment.

While you should speak with your doctor if you’re on chemotherapy, as you recover from chemo, liposomal glutathione may be a good supplement to consider. When cancer cells die, they can release byproducts that increase your body’s inflammatory response, putting more stress on your cells already impacted by chemotherapy.

You may experience brain fog and fatigue well after your chemotherapy, and glutathione can help you regain your energy and neutralize oxidative damage to cells.


Liposomal glutathione is a detoxifier, and it can bind to toxins in the liver and eliminate them.

Because of that, some people take glutathione to help their body more effectively metabolize alcohol.

However, it’s never a good idea to drink excessively even if you find that glutathione helps alleviate some of the effects of doing so.


Sleep deprivation affects many Americans and also increases the oxidative stress in our bodies. This is especially true in the hypothalamus, which regulates our circadian rhythms. Sleep deprivation, along with increased oxidative stress, is also believed to reduce glutathione plasma levels.

Using a liposomal glutathione product can help you get a more restful, restorative sleep.

However, don’t take liposomal glutathione too close to bed. It can give you an energy boost that could make it challenging to fall asleep. It’s best to take liposomal glutathione early in the day.

Pain Relief

Since glutathione has a direct effect on reducing oxidative stress and also serves as an inflammatory modulator, it can create a better response by your body when you have an injury. Liposomal glutathione can also help with general muscle fatigue and joint pain.

Brain Fog and Mental Sharpness

One of the biggest reasons many people use a liposomal glutathione supplement is because it helps reduce brain fog and gives them more mental clarity and sharpness. Liposomal glutathione can also help improve your memory.

It’s a great idea to take liposomal glutathione first thing in the morning to get these effects as well as getting a noticeable boost in energy.

Sometimes people feel a healthy rush of energy within 30 minutes after taking a dose of liposomal glutathione.

Heavy Metal Detox

We all have exposure to heavy metals and other environmental toxins in our daily lives. Toxins, including heavy metals, are in our air, food, water, and the cosmetic products we use.

Glutathione is central to our natural detox process to get rid of these toxins. Glutathione can bind to heavy metals and then make them water-soluble. The result is that they’re eliminated through urine and bile.

What’s often seen in people with heavy toxic loads is that they also have low glutathione levels.

Immune Health

Liposomal glutathione paired with vitamin C can make your immune system a powerhouse.

Glutathione gets your white blood cells, including T-cells and natural killer cells, ready to fight infection effectively. Even if you have an autoimmune disease that causes your immune system to go into overdrive, glutathione can have a modulating effect.

Liver Functionality

Our liver plays a vital role in removing toxins including alcohol and medication. Our liver also works to help our bodies metabolize fats, proteins and carbohydrates.

Glutathione is found in large amounts in our liver because of its role as a detoxifier.

Skin Health

The health and appearance of our skin comes primarily from factors like our nutrition.

Glutathione can help the appearance of your skin by reducing the appearance of wrinkles and increasing elasticity.

Glutathione also blocks an enzyme, tyrosinase, that causes dark pigmentation in the skin that looks like age spots.

Autoimmune Disease

Autoimmune illnesses are increasing in the United States, and they can be triggered by stress, leaky gut, toxins, and alcohol.

When you have an autoimmune disease, your immune system attacks your own tissues. The tissue damage creates oxidative stress, leading to inflammation and symptoms such as fatigue, joint pain, brain fog, memory issues and skin rashes.

Glutathione can be depleted as your body is combatting oxidative stress. Replenishing your body’s glutathione can help with these symptoms.

Leaky Gut

The intestinal lining plays a role in some of our body’s most important functions, including serving as a barrier to prevent toxic substances from entering our bloodstream. The intestinal lining also helps regulate our immune system and it allows us to absorb nutrients properly.

For someone with leaky gut, foreign substances can enter our bloodstream, triggering immune cell responses and inflammation.

The inflammation can become chronic and lead to symptoms like brain fog, skin rashes, and digestive symptoms like IBS and bloating.


Research has shown children with autism tend to have lower glutathione levels. Lower levels of glutathione make it harder to detoxify heavy metals and toxins.

There was a study that looked at the use of transdermal or oral glutathione in autistic children. The supplements increased their plasma glutathione levels.

Higher glutathione levels may help with mood swings, communication, cognition, and speech.

Liposomal Glutathione Benefits

Liposomal glutathione is a certain type of supplement. Liposomal supplements offer a delivery system that ensures effective delivery into the cells and rapid uptake.

Liposomes are especially good as an antioxidant delivery system because they’re prepared from natural phospholipids, are biocompatible and are nontoxic.

What all this means in simpler terms is that liposomal delivery systems are a good way to take supplements like glutathione because they protect the therapeutic molecules from breaking down in your digestive system.

Typically when you take a supplement, and especially one that’s not normally that bioavailable like glutathione, much of the value is lost by the time it reaches your cells because it breaks down in your digestive system.

The goal is to get as much of the value of the glutathione to your cells as possible, which can be achieved through liposomal delivery.

Research found that liposomes can increase cellular delivery 100 times over non-liposomal supplements.

Glutathione is a supplement that’s significantly benefitted when a liposomal formulation is taken.

When you take liposomal glutathione, benefits can include a restored immune system response.

Vitamin C is another supplement that’s well-suited to a liposomal delivery system.

The liposome protects the nutritional compound in liposomal supplements. Then, the phospholipids used to encapsulate the nutritional compound fuse with cell membranes, meaning delivery directly into the cells.

What is the Best Liposomal Glutathione of 2020?

The following are our picks for the best liposomal glutathione of 2020.

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Image Source: Amazon
  • Rather than breaking down in the stomach before reaching the cells, this liposomal glutathione has an advanced delivery system
  • Each 1 mL dose delivers 100 mg of glutathione
  • Supports protection from free radical damage, a healthy immune system and energy levels
  • Gluten-free
  • Rapid trans-mucosal delivery for immediate absorption
  • Made from liposomes small enough to pass between cells so they can directly enter the bloodstream for the maximum amount of bioavailability
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Image Source: Amazon

Pure Encapsulations Liposomal Glutathione

  • BioGlute proprietary blend includes glutathione and essential phospholipids
  • Antioxidant formula to support and protect cellular function
  • Liver detoxification and health
  • Enhanced absorption
  • Hypoallergenic
  • According to reviews, this helps with leaky gut, and it’s easier to take than liquids
  • Immune-system booster
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Image Source: Amazon
  • Combines a blend of 500 mg of glutathione and 500 mg of a liposomal blend
  • Vegan and GMO-free
  • Provides support during times of illness
  • Supports brain health, memory and concentration
  • Protects cells from heavy metals, toxins, and free radicals
  • Made with gold standard reduced glutathione
  • According to reviews, as a master antioxidant, this liposomal glutathione can make anyone feel better on some level
  • May help with fatty liver
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Image Source: Amazon
  • Nano encapsulated glutathione powder pills
  • Made from high-quality pure reduced Setria L-glutathione
  • Delivers 350 mg of phospholipid complex from sunflower oil
  • 30 servings per bottle
  • No fillers, carriers or artificial ingredients
  • According to reviews, this is easier to take for many people compared to a liquid
  • Can help with energy, focus, and clarity
  • May improve digestion
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Image Source: Amazon
  • Pharmaceutical grade liposomal glutathione
  • No artificial preservatives
  • Glutathione is the pure molecule imported from Japan
  • Made with no ingredients imported from China
  • According to reviews, this product clears up brain fog and helps with detoxification
  • Reviews say this product helps with inflammation
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Image Source: Amazon
  • One of the most bioavailable types of glutathione available
  • Includes lactose-free lactoferrin which helps ensure maximum absorption and protection of the glutathione
  • According to reviews, this product is a great energy booster
  • Could be helpful to take if you start feeling sick
  • Some reviews say they use this liposomal glutathione to help with symptoms of Lyme disease
  • Based on reviews, this product helps promote clearer thinking with around 30 minutes of taking it
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Image Source: Amazon
  • Protects you against stress and toxins present in everyday life
  • Stops free radical chain reactions
  • Proprietary liposomal glutathione delivery system for maximum absorption
  • Lab-tested
  • Sugar and glut-free, non-GMO, no added dyes
  • Each bottle contains 30 servings
  • Reviews describe this as a “limitless” pill
  • Reviewers say that taking this liposomal glutathione can lead to a drastic difference in how you feel
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Image Source: Amazon
  • No soy ingredients used
  • Provides 500 mg of pure liposomal glutathione per serving
  • The only liposomal glutathione that uses non-hydrogenated phosphatidylcholine
  • Physician-formulated by Dr. Ben Lynch
  • Reviews say that it helps significantly with brain fog
  • Some reviews compare it to the effects of glutathione delivered by IV
  • May help with adrenal fatigue

Liposomal Glutathione Frequently Asked Questions

The following are some of the common questions people have about liposomal glutathione supplements.

What is liposomal glutathione?

Glutathione is an antioxidant that naturally occurs in all of our cells. We can also use it as a nutritional supplement.

For the best delivery, there’s liposomal glutathione.

Liposomal glutathione is designed to protect the glutathione from the digestive process, so it reaches all the cells and organs of the body quickly and effectively.

Liposomal forms of glutathione protect the degradation that can occur otherwise.

Having optimal levels of glutathione is associated with improved mental and physical health.

What is liposomal glutathione used for?

Liposomal glutathione is used as a master antioxidant.

It can help replace lost glutathione and it’s involved in the metabolism of carcinogens and toxins, DNA repair, and immune system function. Taking liposomal glutathione can also help prevent oxidative cell damage.

How do you take liposomal glutathione?

There are a couple of different types of liposomal glutathione. There are capsules, which some people find easier to take because otherwise, the product can have a strong flavor and odor.

There are also liquid forms of liposomal glutathione, which you may prefer if you want to maximize absorbency even more than what you already get with the liposomal delivery system.

What does liposomal glutathione do?

Liposomal glutathione is used for a variety of purposes, and many experts, including Dr. Ben Lynch, feel that it’s one of the most important supplements you can take because glutathione is in every cell of our bodies.

Liposomal glutathione can improve your energy levels and mood, can regulate your immune system function, and it’s called the master antioxidant.

When should you take liposomal glutathione?

It’s advised that you take liposomal glutathione first thing in the morning to get a boost of energy.

You might also take a dose in the early afternoon.

Don’t take glutathione too close to bed, however, because it can interfere with sleep. When taken early in the day it has the effect of actually improving your sleep quality. 

What is the best liposomal glutathione on the market?

Above, we highlight some of the best liposomal glutathione on the market based on factors including the reputation of the company making it, as well as customer and user reviews.

There are any liposomal glutathione side effects to be aware of?

Liposomal glutathione doesn’t have any major, known side effects. If you experience side effects, they’re most likely to be mild and may include digestive upset.

Summing Up—Liposomal Glutathione Benefits

Liposomal glutathione is a supplement you should consider taking regularly. It can improve your focus, concentration, mood, and memory.

Glutathione is also found in all of our cells, but illness and aging can reduce how much of it naturally occurs in our body.

A supplement can replace glutathione and also help our immune systems, the appearance of our skin, and may reduce symptoms of serious illnesses.

While there are many benefits of a liposomal glutathione supplement, always speak to your health care provider before taking anything.













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