best cbd cream for neuropathy pain

What is the Best CBD Cream for Neuropathy Pain?

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Last modified on October 27th, 2022

Below is a guide to the best CBD cream for neuropathy pain. We base our reviews for the best CBD cream for neuropathy pain on:

  • Ingredients/Potency
  • Customer reviews
  • Price
  • Availability
  • Overall effectiveness

We’ll provide you with an overview of each of our picks and a more detailed review of the four best CBD creams for neuropathy pain.

Best CBD Cream for Neuropathy Pain #1: Medterra 250 mg CBD Rapid Cooling Cream


  • High 250 mg dose of CBD
  • Roll-on applicator
  • Cooling effect for both joint and muscle support
  • It also contains arnica and menthol


  • Some people don’t like the smell

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Medterra 250 mg CBD Rapid Cooling Cream Overview

Medterra’s Rapid Cooling Cream is pain relief and muscle recovery. In one bottle, the total amount of CBD is 250 mg, with 5 mg per 1 mL of product. The cream is THC-free, and it’s highly rated among users.

We like Medterra because it comes as a roll-on, and the brand is known for quality products with beneficial effects. This product is easy to use anywhere, anytime, and you can take it on the go. We also like its rapid cooling effect for nearly instantaneous relief.

Along with being one of the best options for a CBD cream for neuropathy pain, it can help with other types of pain, including joint and muscle pain.

We highlighted the 250 mg strength product, but Medterra has other strengths, so you can find what works for you.

Medterra is a full-spectrum hemp extract, with a 5:1 ratio of CBD to other cannabinoids.

Full-spectrum CBD tends to be the best option for neuropathy because it contains all of the phytonutrients of hemp, such as flavonoids and terpenes. The compounds all work together for amplified health benefits.

Medterra’s hemp can help with pain management, inflammation management, and neuroprotection of the foot when you suffer from neuropathy.

Best CBD Cream for Neuropathy Pain #2: Sagely Calm & Centered Cream


  • Gentle, soothing formula
  • Created by scientists and naturopaths
  • High-quality, broad-spectrum CBD
  • Includes essential oils
  • 250 mg of CBD


  • Might not be potent enough for some users

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Sagely Calm & Centered Cream Overview

We love the Calm & Centered CBD cream from Sagely, and it’s a top-rated product among customers. The current formula has 250 mg of CBD. Both scientists and naturopaths formulated the product.

Sagely’s Calm & Centered Cream is broad-spectrum CBD and has soothing, calming essential oils, including lavender, bergamot, and chamomile.

Lavender oil promotes clarity and peace in this cream for pain. Bergamot oil elevates the mood and positivity. Chamomile oil helps with calm and relaxation.

The product is vegan, made in the U.S, and contains no detectable THC. There are no parabens, heavy metals, sulfates, synthetic fragrances, or artificial colors or dyes.

According to customers, they love Sagely Calm & Centered because they like the natural ingredients, they feel like it works quickly and smells great. Most users describe it as a smooth and creamy product that is easily absorbed. They find it a generally relaxing sensory experience that helps with pain, including neuropathy pain.

Best CBD Cream for Neuropathy Pain #3: Nanocraft CBD Muscle and Joint Stick


  • 500 mg of broad-spectrum CBD
  • Includes ginger root and Boswellia serrate for more pain relief
  • On-the-go application
  • High-rated by users
  • Works quickly


  • More expensive than other options

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The Nanocraft CBD Joint Stick includes 500 mg of broad-spectrum CBD. This extra-strength product also has essential oils and natural herbs to promote rest, recovery, and relaxation. The product is made in the United States, is lab-tested, and features a 30-day money-back guarantee.
Nanocraft’s CBD Joint Stick includes beeswax ginger and shea butter. Another one of the active ingredients is Boswellia serrate, which provides more anti-inflammatory and quick relief from pain and sore muscles.

The broad-spectrum hemp is combined with oil distilled, and the extract comes from food-grade ethanol. Nanocraft is one of the few companies that uses food-grade ethanol in its extraction process.

We like that this CBD foot cream and neuropathy cream provides easy application and is vegan and cruelty-free.

Best CBD Cream for Neuropathy Pain #4: Medical Miracles Hemp 1000 mg Healing Salve


  • Extra high-potency with 1000 mg of hemp
  • It contains healthy omega fats for skin health
  • Made with high-quality ingredients like coconut oil and beeswax
  • Fragrance-free
  • Made in the U.S.


  • Some batches have a grainy texture, according to reviews

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Medical Miracles 1000 mg Hemp Salve is perfect for joints, including your small and large joints, like your hips, back, elbows, knees, and fingers. All the products are made from ingredients grown in Colorado, and the product line comes from non-GMO and preservative-free hemp.

The formula includes omega fatty acids for soft, moisturized skin and reduced inflammation.

Natural ingredients in the Medical Miracles Hemp Healing Salve include beeswax, which creates a protective layer on the skin, sweet almond oil, shea butter, and coconut oil. The formulation also includes lavender essential oil.

There are no parabens or fragrances.

Most of the reviews say this product works better than any other CBD cream or salve for various types of pain. Some reviewers even say it’s a life-changer, and they like that in addition to being effective, it doesn’t have an overpowering scent which many are sensitive to.

What is Neuropathy?

Neuropathy, also known as peripheral neuropathy, results from damage to the nerves that are outside of your brain and spinal cord.

These nerves are known as your peripheral nerves.

Peripheral neuropathy can occur because of injuries, metabolic problems, infections, and toxin exposure. One of the most common reasons people experience neuropathy is diabetes.

The associated pain is often described as burning, tingling, or stabbing. Symptoms can improve in many cases, particularly if a treatable medical condition causes neuropathy.

Signs of peripheral neuropathy may include:

  • Gradual numbness, tingling, or prickling that starts in the hands and feet and can spread up into the arms and legs
  • Sensitivity to touch
  • Sharp, burning, jabbing, or throbbing pain
  • Pain during activities that wouldn’t otherwise be uncomfortable, like experiencing pain when your feet are under a blanket
  • Muscle weakness
  • Lack of coordination
  • Feeling like you’re wearing socks or gloves even though you’re not

Many autoimmune diseases can cause peripheral neuropathy like lupus, rheumatoid arthritis, and Sjogren’s syndrome. More than half of all Americans with diabetes will develop neuropathy, and other disorders associated with the condition include connective tissue disorders, hypothyroidism, and kidney or liver diseases.

Vitamin deficiencies associated with peripheral neuropathy include B vitamin deficiencies, and deficiencies of vitamin E and niacin, all of which play an essential role in nerve health.

What is CBD?

Cannabidiol is also referred to as CBD. It’s a cannabinoid, a compound found in cannabis, that doesn’t produce a high. THC is the compound in marijuana that makes someone high.

There are cannabinoid receptors located throughout your body. Researchers have identified two major types so far—CB1 and CB2.

CB1 is mostly in your central nervous system, including your brain and spinal cord. CB2 is primarily in the tissues of the immune system, and both are in the skin.

While THC seems to bind to and then activate these receptors, the effects of cannabidiol seem to be more modulating. That means it can block the results of the CB1 and CB2 receptors, so the effects of CBD may be more related to regulation. For example, CBD could help regulate inflammation associated with pain.

CBD may also interact with areas of your body outside of your CB receptors. For example, in a recent review, CBD affected some serotonin receptors, which play a role in anxiety and depression. CBD was also found to impact adenosine receptors, one of the neurological targets that caffeine affects.

Is CBD Cream Good for Neuropathy Symptoms?

When you take a skin cream marketed as a CBD product, it contains cannabidiol or CBD. The idea is that CBD creams can reduce the inflammatory response and have analgesic effects.

CBD is just one of many chemicals in the Cannabis Sativa plant. These products usually contain little to no THC, which is what makes you feel high in the marijuana plant.

Research shows that CBD creams can help with skin and joint conditions symptoms, although more research is needed on the topic.

In a study released in 2020 that specifically looked at the effects of topical CBD on the relief of neuropathy, there were found to be significant benefits. Overall, there has been a growing body of evidence to support CBD products, including creams and topicals, to relieve chronic pain.

Using a cream topically can provide relief on both a surface level and deeper into the muscles. A lot of users find these creams also help them relax and sleep.

Other conditions that topical CBD creams can help with include arthritis and skin conditions like eczema, psoriasis, and acne. In 2019, a study found people who notice jaw pain from temporomandibular disease or TMD experience improvements in their condition after using CBD.

How Does Topical CBD Help with Pain?

Many people wonder whether or not using a topical product like a CBD cream for neuropathy pain is going to be effective. When you choose a high-quality, potent CBD cream, research does show it can help with at least temporary relief from pain.

The reason for the therapeutic benefits?

Our skin has a high concentration of cannabinoid receptors. When you apply CBD directly to your skin, or topically, it activates your endocannabinoid system through the receptors.

The CBD in the cream binds to your cannabinoid receptors located in your dermal and epidermal skin, alleviating pain and inflammation.

Topical CBD can work anywhere you apply it, but it will not give you full-body pain relief like taking it orally might.

Your skin is very absorbent, and it’s going to absorb all the other ingredients in the cream you use as well, so keep that in mind.

What CBD Product is Good for Neuropathy?

Neuropathy or nerve pain is different from some other types of pain. Neuropathic pain affects your nervous system, causing shooting, burning, or stinging discomfort. Diabetes and similar chronic conditions can increase the risk of developing nerve pain.

There is promising evidence that CBD can be helpful. When choosing the best CBD cream for neuropathy pain, consider the following factors:

  • Potency: The doses of CBD in a product can vary quite a bit. You also have to remember that the number of doses per bottle isn’t the same as the individual dose. For example, a product might have 1000 mg of CBD in the container, but only around 5-10 mg per dose. That’s pretty normal and does allow you to start with a small dose and then work your way up as you need.
  • Type: The best CBD cream for neuropathy pain is usually one that’s full-spectrum. Full-spectrum CBD tends to be more effective than CBD isolate. A CBD isolate is a highly purified form of the cannabinoid. If you try an isolate and it doesn’t give you results, it’s worth trying a full-spectrum product.
  • Quality: The FDA doesn’t approve or regulate CBD products, so you should try to choose creams that have independent testing and verification of their ingredients.
  • Ingredients: The best CBD creams for neuropathy pain highlighted above are excellent because they have clean, pure ingredients. Try to steer clear of things like artificial fragrances or coloring. The simpler and more natural the ingredients, the better. Look for organic ingredients and all-natural ingredients when possible.

Best CBD Cream for Neuropathy Pain—Final Thoughts

Trying one of the best CBD creams for neuropathic symptoms may be a worthwhile option. CBD is considered very safe, particularly when used topically.

Some people find that it does give them relief from their neuropathy pain, especially if you choose high-quality, potent, and full-spectrum CBD products.

Along with CBD from the cannabis plant helping with neuropathy, it may have other pain-relieving effects. For example, extracts from hemp plants in topical cream could help with joint pain, with minimal potential side effects and no psychoactive effects.

CBD creams can be one of the better natural alternatives to deal with pain signals for a lot of people.

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