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Onnit Alpha Brain Review

Last modified on February 22nd, 2023

If you’re looking for a real Alpha Brain review, we finally put one together. The Alpha Brain supplement from Onnit is tremendously popular, particularly since Joe Rogan endorses it. With that being said, does it live up to the hype?

Specifically, in our Alpha Brain review, we’ll go over what this supplement is supposed to do, how it works, and the ingredients. We also researched some real customer reviews so you can find out whether or not it delivers.

Overall, according to the Onnit brand, this nutritional supplement, which contains ingredients like bacopa extract, vitamin B6, cat’s claw extract, and other ingredients, is meant to support cognitive functions. Taking Alpha Brain supplements is also supposed to help brain performance, and alpha brain wave production, help support cognitive functions, lead to a more positive mood, and promote an overall healthy brain environment.

Alpha Brain Benefits

Onnit Alpha Brain thus far has sold more than a million bottles. Possible benefits of Alpha Brain include:

  • Reduced brain fog
  • Increased focus
  • No crash
  • Stimulant-free
  • Created with natural ingredients like bacopa and cat’s claw
  • Alpha Brain is one of the original top-selling nootropics
  • Supports memory
  • Endorsed by Joe Rogan
Alpha Brain claims to improve cognitive function. The Onnit company has its headquarters in Austin Texas but the Unilever acquired the company in 2021. Joe Rogan was a co-founder of this mental performance supplement.

So how does Alpha Brain theoretically achieve all of the above? Below we go into the research about each of the individual ingredients, so you can learn more about whether or not this product is right for you and also whether the science supports the claims above.

We should also note that, as was touched on above, Alpha Brain is considered a nootropic. A nootropic is a supplement that supports the functions of your brain, including your focus, mental speed, and memory.

Specifically, Alpha Brain is designed to help support your natural production of neurotransmitters, which are chemicals that move information around in your brain, and also to make more alpha waves.

Alpha Brain can help create an optimal environment for your brain to function at its best basically. So, with that in mind, we continue with the rest of our Alpha Brain review.

This nootropic supplement when used by healthy adults may have some benefits to support cognitive performance, although the reviews are somewhat mixed.

What Are Alpha Brain Waves?

The Alpha Brain supplement is often associated with the term alpha brain waves, so having an understanding of what this actually means could be helpful if you’re reading this review to decide if you want to buy the product.

There’s constant electrical activity going on in your brain because your neurons are communicating with one another. There are five types of brain waves. They vary from moving very slowly to very fast.

Alpha waves are in the middle.

You typically produce alpha brain waves when you are awake, but you’re not focused on any particular task.

When you wake up in the morning, for example, you might be adjusting to getting up and starting to think about preparing for your day, but you aren’t trying to solve challenging problems or processing big chunks of information.

When you’re producing alpha waves, you tend to be fairly relaxed and calm.

Research has shown that when you do things like meditate, your brain responds with alpha waves.

When you’re producing alpha waves, you can feel more of a sense of well-being. You can also be more creative when you’re producing alpha waves.

There was a study in 2015 where researchers found that they could trigger a burst of creativity if they worked to specifically increase alpha waves.

There’s also research that shows if you have depression, you may have an imbalance of alpha waves. In a small study carried out in 2019 with a brain stimulation technique, researchers found alpha waves could be increased, which could reduce symptoms of depression in people with major depressive disorder.

About the Onnit Company and Brand

Onnit is headquartered in Austin, Texas. This is a health and wellness company, and they said they encourage peak performance by offering unique products but also actionable information.

Joe Rogan is the co-founder of Onnit, and he’s a big promoter of the company, which was sold to Unilever in 2021.

Alpha Brain Ingredients

For our Onnit Alpha Brain review, we think it’s important to break down each individual ingredient and the science that supports its benefits. This also tends to be the best way to determine if there are any possible side effects.

Onnit Flow Blend

Each of the ingredients in this supplement, as you’ll figure out by reading the rest of this Alpha Brain review, is grouped into categories. These are proprietary blends, which we talk more about the pros and cons of later in the Alpha brain review.

The Onnit Flow Blend is the first. The Onnit Flow Blend includes:

  • L-theanine: This is an amino acid that triggers the release of feel-good neurotransmitters in the brain, which are serotonin and dopamine. These are hormones that help with relaxation by increasing alpha-wave activity. L-theanine can also help improve reaction time and attention.
  • L-tyrosine: This amino acid helps your body naturally produce dopamine and adrenaline. It has been shown to help with cognitive performance, particularly when you’re facing a stressful situation.
  • Phosphatidylserine: This is a fat that’s in our cell membranes, and it also plays a valuable role in the function of our brain.
  • Oat straw extract: Oat straw comes from a plant called Avena sativa. It may have a number of health benefits, including improved mood and brain function and reduced inflammation. It’s also high in zinc, manganese, and iron. Some people feel that it helps with stress and it may improve physical and sexual performance.

According to Onnit, the goal of the above ingredients is to promote a “flow state,” which would mean more alpha brain wave activity. When your alpha brain waves are high, research shows that you’re calmer, more focused, and more organized.

This formula also includes cat’s claw. Cat’s claw has a lot of purported benefits. For example, it may help improve the immune system, and it may help with rheumatoid arthritis.

It may also help promote general cellular health.

Onnit Focus Blend

The Onnit Focus Blend is the next set of ingredients we’re going to cover in our Onnit Alpha Brain review.

The Focus Blend includes something called Alpha-GPC. This is a precursor to acetylcholine, which is one of our most important neurotransmitters. Acetylcholine controls hormones, muscle cells, and nerves.

The Focus Blend has Huperzia Serrata, which can help reduce the breakdown of acetylcholine. Huperzia Serrata has been shown in some studies to improve memory and protect the nerve cells of the brain. It’s even used in Asia as a treatment for Alzheimer’s and vascular dementia.

The third ingredient in the Focus Blend is Bacopa Monnieri, which is also called Brahmi. This is one of the most interesting ingredients in the world of nootropics to us right now. Bacopa has been used by Ayurvedic practitioners for thousands of years to help with treating epilepsy, reducing anxiety, and improving memory.

Research does show it may help with anxiety and stress, and it may also improve brain function.

This Alpha Brain review delves into everything you know about taking these supplements, and whether or not they're effective.

Onnit Fuel Blend

The Onnit Fuel Blend, according to the maker of this supplement, is meant to help create a healthy and optimized brain environment and fuel neural communication.

One ingredient in the Fuel Blend is called pterostilbene. This is a derivative of resveratrol. Pterostilbene is the main antioxidant in blueberries, and it’s been shown to have anti-cancer and anti-inflammation effects as well as benefits for vascular and neurological diseases.

L-leucine is a branched chain amino acid or BCAA. Leucine is an amino acid used in protein synthesis. It also plays a role in many cellular functions and processes, including metabolism and tissue regeneration.

Are There Any Alpha Brain Side Effects to Be Aware Of?

As part of this in-depth Alpha Brain review, we did significant research to figure out if we could find any side effects related to this nootropic supplement.

Overall, Alpha Brain is considered a safe nootropic, but you should talk to your doctor and go over all the ingredients and any medications you take first. This is true of any supplement.

Possible but rare side effects we found for Alpha Brain include

  • Nausea and stomach upset
  • Headaches
  • Vivid dreams
  • Anxiety or jitters
  • Sleeplessness

There is another potential Alpha Brain side effect to be aware of related to the ingredient Huperzine A.

Huperzine A is an inhibitor of something called acetylcholinesterase. This means that acetylcholine slowly builds up in your brain, and that can have positive effects like improved concentration and reaction times.

However, if you have too much acetylcholine in your brain, it can have opposite effects. For example, you could experience headaches, confusion, low mood, and a lack of motivation. If the acetylcholine keeps building up more in your brain, you may have more severe side effects like cognitive impairment, muscle cramps, blurred vision, and muscle cramps.

The best way to avoid this type of side effect is to first use Alpha Brain only as instructed and not to exceed the maximum dosage.

The other way is to cycle your use of Alpha Brain. This is recommended with all types of supplements.

Essentially this means that you don’t take Alpha Brain every day, or you give yourself days off from taking it on a regular basis. This will not only help prevent side effects, but it can also keep the supplement working well.

Clinical Research

One of the most compelling things about this supplement that wanted to make us do our own in-depth Alpha Brain review is the fact that randomized, double-blind controlled studies have been done looking at its effectiveness.

That’s rare to find with supplements. In one study, the use of Alpha Brain for six weeks significantly improved recent verbal memory in a group of adults compared to a control, for example. It also included executive functioning.

How Do You Take Alpha Brain?

You should take only two Alpha Brain capsules a day. Don’t exceed that. You should also talk to your doctor before using it. The instructions indicate that it’s best to take Alpha Brain with a light meal. We suspect this is pretty important because it can help reduce the risk of nausea or other stomach-related side effects that some people do experience.

Onnit Alpha Brain Review: What Do Real Users Say?

As part of our own Alpha Brain review, we looked at a variety of sources to see what real customers and users have to say about Alpha Brain, its effectiveness, and any possible downsides.

First, as far as Reddit reviews, they’re not great. A lot of people writing an Alpha Brain review on Reddit said they got no noticeable difference from using it, including when they took a double dose. Several users said that even though they took it for a few weeks, it had no effect.

With that being said, there seems to be a difference, at least according to Alpha Brain reviews on Reddit, for people who take it for a few months versus a few weeks. People who take it long-term definitely said they get results.

Some users on Reddit reviews did experience side effects from taking Alpha Brain, such as anxiety and vivid dreams.

We also noticed something worth pointing out among people on Reddit who leave an Alpha Brain review—they feel a little misled by Joe Rogan because many of them started using it due to his endorsement.

There are, of course, users on Reddit who say they get results in the shorter term from Alpha Brain. For example, some say it made them feel mentally sharper. According to some Alpha Brain reviews on Reddit, people also say it helps them process their thoughts a little easier.

There are Reddit users who stack Alpha Brain with other products, like lion’s mane, and feel that gives them better results.

The Amazon Alpha Brain reviews were more favorable.

Of the nearly 9,000 current Alpha Brain reviews on Amazon, the average rating is 4.5 stars out of 5.

We should note that while many of the Alpha Brain reviews on Amazon said it was a helpful product, there was a fair amount of them who had symptoms, including nausea and vomiting. Some people also said they had hot flashes when taking this product.

The highlights among the favorable Alpha Brain reviews were clearer thinking, more productivity and reduced brain fog.

Another downside of Alpha Brain is that it’s expensive at nearly $80 a bottle if you get 90 capsules.

Pros of Alpha Brain?

Some of the ingredients in this supplement are actually well-proven and excellent nootropics that may end up being helpful for some people. This is especially true of Bacopa monnieri, Alpha-gpc, and phosphatidylserine.

I take each of these three supplements daily, but not in the Alpha Brain formulation, and I find them to be enormously beneficial for my mood, focus and concentration, and overall sense of mental well-being.

What Are the Cons of Alpha Brain?

As part of our overall Alpha Brain review, we want to point something out.

All the ingredients in Alpha Brain are part of what’s called a proprietary blend, and there’s no clear indication as to how much of each product is in it.

While this does make taking a lot of supplements at one time more affordable, it tends to make them less effective. Usually, when there are proprietary blends in a product like Alpha Brain, there are very low doses of each individual ingredient.

While this could be fine for some people, and there are thousands and thousands of users who say they get benefits, for other people, it might be better to take some of the individual ingredients at higher doses.

Does Alpha Brain Work?

According to reviews of people who love Alpha Brain, it can undoubtedly help some people. Does Alpha Brain work for me?

Personally, it doesn’t, and I prefer to take some of the individual ingredients to support focus and enhance cognition and mood. For my personal brain chemistry, I feel that Alpha Brain simply is too weak of a product because there are small amounts of each ingredient, and I think that it works better for me to take the ingredients I like individually for the maximum effects.

Everyone is different, and the ingredients and research do support this brain-focused supplement, so it may be something you have to try on your own to see how it works for you.

Is Alpha Brain FDA Approved?

No dietary supplements can be approved by the FDA in the U.S., and Alpha Brain is no exception. It’s not FDA-approved since the Food and Drug Administration doesn’t regulate dietary supplements. If you purchase Alpha Brain products, you should do so with that in mind.

What Is Alpha Brain Black Label?

One of the newer offerings from the Onnit Brand is the Black Label product. According to the Onnit company, Black Label is a “refined” formula. It includes caffeine and a couple of other ingredients that are unique from the original formula. These ingredients are:

  • Citicoline is a brain chemical that can help maintain levels of neurotransmitters to support focus and attention.
  • The form of caffeine in the supplement is actually caffeine anhydrous, which is a concentrated form that, along with the included L-theanine, can support feelings of “alert relaxation” and a positive mood.
  • Lutemax 2020 is included in Black Label and is a naturally occurring compound that comes from the marigold flower. The extract contains lutein and zeaxanthin, which are carotenoids from plants that support eye function and visual performance. These can help with the maintenance of brain and eye health, and they may help filter blue light entering the eyes.
  • Mucuna pruriens contains L-dopa, which is thought to increase dopamine, supporting a positive mood.

According to Onnit, if you’ve already tried the regular formula and found yourself disappointed, you may have a better experience with the more potent Black Label. You might also want to use the supplement when you need deep focus, especially during stressful times.

Alpha Brain Black Lable has some addition ingredients from the original formulation. This dietary supplement for example includes caffeine, whereas the original formula doesn't.

Are There Better Alternatives?

As I continue to mention in this review, for me, rather than taking Alpha Brain or any proprietary blend, I think the individual ingredients are more effective at supporting cognitive function, mood, and focus. The following are four of my favorite supplements that, based on my experience, clinical trials, and research, can support many of the same goals you might have in trying Onnit Alpha Brain. My list of must-have brain-boosting supplements are:


One of my favorite supplements for mood, focus, and concentration is a compound called DMAE. I find that it’s one of my most effective cognitive and mood boosters. I take it as a powder. There’s evidence to suggest that DMAE may help with ADHD symptoms, Alzheimer’s disease, depression, and dementia. It’s also sometimes called Deanol, and it’s naturally produced in the body and found in fatty fish like salmon.

DMAE is thought to work by increasing the production of acetylcholine or Ach. Ach is a neurotransmitter that helps brain cells send signals to one another. Ach helps with many of the functions your brain controls.

DMAE might also help prevent the buildup of beta-amyloid in the brain. Too much beta-amyloid might play a role in memory loss and age-related cognitive decline.

Find a review of Onnit Alpha Brain, and information about better alternatives to protect brain cells and promote cognitive function.

Mucuna Pruriens

Mucuna pruriens is also known as the magic velvet bean or the dopa bean. It’s an adaptogen, and it is a natural source of levodopa or L-dopa. This is a precursor to dopamine. I like mucuna pruriens because I feel that it contributes to a better mood and sense of well-being.

The herb also reduces feelings of stress and promotes the health of the nervous system, including the brain.

This is one of Alpha Brain's ingredients in the black lable formulation, but it's not in the regular formula. Mucuna pruriens can support the brain and nerve cells, and may have some of the same benefits of taking alpha brain.


L-theanine supports cognitive function. This amino acid can help you get into that flow state, where you’re calm but focused, and it’s excellent when stacked with caffeine. As a naturally-occurring amino acid, L-theanine is found in mushrooms and tea, and you can also take it as a supplement, which I do daily.

This amino acid helps support cognitive functions, focus and a calm sense of concentration.


L-tyrosine is a nonessential amino acid, and it’s needed for the production of critical neurotransmitters like dopamine, norepinephrine, and epinephrine. I take it every morning, and it’s been a game-changer for me in terms of brain health, concentration, focus, and my general sense of well-being.

Final Thoughts—Does Onnit Alpha Brain Work?

In this Alpha Brain review, we’ve given you a lot of information, so we wanted to sum it all up and provide our recommendation as to whether or not it might be worth trying.

  • Alpha Brain has great ingredients that have been proven to help with mental health, focus, and concentration, as well as having other benefits.
  • The Onnit Alpha Brain reviews are mixed. Some people think it’s a great supplement, but it doesn’t work for everyone.
  • For the people Onnit Alpha Brain doesn’t seem to work for, it might be better to explore taking some of the ingredients individually.
  • Some of the most proven ingredients in Alpha Brain include L-theanine, L-tyrosine, Alpha-GNC, and Bacopa.
  • While there isn’t evidence of major side effects related to Alpha Brain, some users report things like nausea, vomiting, vivid dreams, and headaches.

Our takeaway? Based on our Alpha Brain review, we’d say it has the potential to be a good supplement for some people to reduce anxiety and stress and improve thinking and concentration. It may not work for everyone, and some people might benefit from getting higher doses of some of the ingredients. This is a common downfall of a supplement with proprietary blends rather than single ingredients.

While Joe Rogan often touts Alpha Brain, we think some people will find it very helpful and other people won’t. It may just come down to getting the okay from your doctor and then trying it for yourself.

Our Editorial Process

All of our reviews are completely unbiased. We have an in-depth review and ranking methodology for each of our products. We base our reviews on:

  • Peer-reviewed scientific studies and research
  • Real customer reviews
  • Our own experience using products
  • Price and availability

Whenever possible, we review and rank products that we actually use to provide a better understanding of what you can expect. 

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