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Last modified on January 9th, 2023
Tru Niagen could be an incredibly important supplement for many people, which we’ll delve more into below. This supplement helps increase NAD+, and it has a lot of scientific research backing it up.
One of the reasons we decided to cover this Tru Niagen review is because it has a lot of clinical evidence about its potential benefits and effects, which can be hard to find in a supplement.
Below, we’ll explore everything you need to know about this NAD-increasing supplement and the science behind it.
What Are the Benefits of Tru Niagen?
According to the company that makes this supplement, benefits may include:
- Increasing NAD+ levels for cellular defense and protection from everyday stressors
- Healthy aging
- Improves metabolism for overall health and well-being
- Replenishes your cellular energy, so you’re better able to maintain an active, healthy lifestyle
- Promotes cellular repair to counteract the effects of aging, exercise, and stress on the body
- Resetting your internal clock
- Repairing damaged DNA, which could reduce cancer risk
The main idea behind the use of this supplement is that it helps you maintain optimal cellular health. Your cells are the foundation of good health, and they take on a lot of stress over time. When you care for your body at the deep, cellular level, it nourishes all of you.
Some critical stressors affecting your cellular health include aging, unhealthy sleep patterns, sun exposure, and overtraining during your workouts.
The bioscience company that makes this product is ChromaDex. They created Tru Niagen in 2013, and since then, it’s become a top-selling supplement. The ChromaDex company works with Nobel Prize-winning scientists, and they also publish peer-reviewed clinical studies in humans.
What is Tru Niagen?
Tru Niagen is the only patented form of something called nicotinamide riboside or NR in the world. NR is found in some foods, but you can’t get enough from diet alone to increase your NAD+ levels. NAD+ levels go down as you age because of a lack of sleep, alcohol consumption, intense exercise, and more.
In 2004, Dr. Charles Brenner discovered NR, a naturally occurring micronutrient in milk that increases NAD+ levels by 40% to 50%.
Nicotinamide riboside is also known as niagen. It’s an alternative form of niacin, also called vitamin B3. NR is the active ingredient in the Tru Niagen dietary supplement.
As is the case with another form of vitamin B3, nicotinamide riboside is converted by your body into the coenzyme nicotinamide adenine dinucleotide or NAD+.
NAD+ is essential for many of your biological processes, including general cellular function, repairing damaged DNA, setting your internal clock, and converting food to energy.
When you have low NAD+ levels, it is associated with some of the most devastating chronic illnesses including Alzheimer’s, vision loss, heart disease, and diabetes. In animal studies, when you raise NAD+ levels, it may help reverse signs of aging, along with lowering your risk of developing many chronic diseases.
A niagen supplement like Tru Niagen can help raise NAD+ levels, supported in human and animal-based scientific studies.
The Importance of NAD+
NAD+ is perhaps one of the most important things to learn about supplements, anti-aging, and overall health and wellness. It’s really on the cutting edge of all of these things.
To understand why Tru Niagen is such a valuable supplement, it’s good to understand NAD+ in more detail.
NAD+ is a vital coenzyme in every cell of our bodies, involved in hundreds of metabolic processes.
The two key roles it plays, as we’ve briefly touched on, are regulating metabolism by turning nutrients into energy and helping proteins that regulate other cellular functions. First discovered in 1906, NAD+ has continued to be front and center as far as eliminating illnesses and reversing signs of aging.
Precursors of NAD+ include nicotinamide, nicotinic acid and NR.
NAD functions in your cell’s mitochondria often called the powerhouse of your cells. They produce energy for all of your other cellular functions, and 90% of your energy comes from your mitochondria. Without NAD+, your production of energy would end. You need NAD+ to pump blood, breathe oxygen, and essentially everything else you do.
One particular way that NAD+ seems to have significant health benefits is by helping sirtuins do their jobs adequately. These proteins regulate biological pathways, turn genes on and off, and protect our cells from declines related to age.
NAD+ increases the activity of SIRT1, which is one type of sirtuin. SIRT1 may help your body form new mitochondria and extend your lifespan. NAD+ can also help with the formation of SIRT6, which maintains the length of your telomeres. Longer telomeres are linked to longevity.
When you have declines in NAD+ and as a result, reductions in SIRT enzymes, the results can include:
- Brain neurodegeneration
- Vascular inflammation can cause damage to the blood vessels leading to heart attack or stroke
- Higher fat storage in the liver, leading to nonalcoholic fatty liver disease
- Increased fat production
- More fat storage in the belly area
- Insulin resistance
- Loss of muscle strength
Below, we break down more precisely the health and lifestyle benefits of NAD+.
Age-Related Memory Loss
NAD+ is essential for DNA repair, and it helps your body resist neuronal and metabolic stress. As a result, it can improve your memory and slow down declines in your memory related to aging.
In one animal study recently, researchers added a supplement like Tru Niagen to their water after mimicking human memory declines related to age. The mice took the supplement for three months. The researchers found over this period, the mice treated with the supplement had more neuroplasticity, less DNA damage, more production of new neurons, and reduced neuronal damage.
In the hippocampus, where the loss of volume and damage is linked with memory problems, the NR supplement seemed to eliminate the existing DNA damage or prevent it from worsening.
The NR-treated mice also did better on memory tests.
Research in animals shows that having higher levels of NAD+ may support a healthy metabolism. It may also help with weight maintenance as you age, even if you consume a high-fat diet.
Muscle Performance and Endurance
In a mice study, when the animals were given NR as a key ingredient, they had more sustained energy and improved insulin sensitivity. Both are factors that indicate optimal levels of vitality.
On a treadmill test, animals with an NR supplement ran 33% further than the control animals, showing improvements in performance and endurance, boosting the benefits of physical exercise.
Essentially, what researchers believe is that NR can help with not only general longevity so that you feel your best, but it can turn off genes related to aging.
Why NAD+ Isn’t Good As a Standalone Supplement
You might be thinking now that you want to run out and get an NAD+ supplement. However, a direct form of supplementation may not be your best option. NAD+ taken directly as a supplement can’t enter your cells.
Your body breaks down the NAD+ that you take orally into smaller molecules. Then, after they’re in your cells, they have to re-assemble. All of this makes direct NAD+ supplementation inefficient.
The best way to boost your levels is to use a B3 supplement.
Vitamin B3 is a precursor to NAD+, meaning it’s a building block.
The three primary forms of vitamin B3 are:
Niacin is an inexpensive, easy-to-find supplement, but one reason some people don’t like it is because of the niacin flush.
Nicotinamide, also called NAM, doesn’t have any side effects, but it can inhibit sirtuins, which we talked about above as being an essential part of cellular repair.
Then, there’s NR.
NR represents an important point in the research surrounding NAD+.
NR is one of the most efficient ways to elevate NAD+ levels, and there aren’t any known adverse side effects.
Tru Niagen is a nicotinamide riboside, which can effectively and efficiently enter your cells for the most benefits.
How Long Does It Take Tru Niagen to Work?
The recommendation, based on clinical trials, is that you take 300 mg of daily supplementation.
Then, based on this research, subjects who took the 300 mg once a day experienced an average increase of 40%-50% in whole-blood NAD+ in around two weeks.
Within the first two weeks, you may start to notice increases in your energy levels. It’s imperative to be consistent in taking it.
Then, within 2 to 4 weeks after you start taking the supplement, you should begin to feel like your energy levels are going up even more. You are giving your cells a steadily increasing supply of NAD+. At the four-week point and beyond, you should start to feel more profound anti-aging effects. Your energy levels are likely to go up more, you may notice better workouts, and you can feel the complete nourishment in every cell.
What Do Tru Niagen Reviews Say?
The customer reviews for this product are great, which is one more reason that we believe it’s a product worth trying with significant potential health benefits.
There are thousands of customer reviews, with many customers saying they noticed benefits very quickly. For example, many customer reviews said they felt they were exercising more and they had clearer thinking.
Customer reviews say they were able to handle stress more effectively when they started using this NR supplement, and their energy levels were significantly increased. The energy production didn’t come with the jitters, however, based on reviews. Instead, it was a clean, steady stream of energy but not accompanied by anxiety.
When it’s time to go to bed, users say they notice that they sleep better.
Other positive health benefits we noticed customers saying they got with consistent use of this supplement include less pain, hair regrowth, lower blood pressure, and improvements in their sense of well-being.
Clinical Niagen Studies
We wanted to highlight some of the studies that show Niagen, which is the patented form of nicotinamide riboside in Tru Niagen, is effective at helping elevate your NAD+ levels.
- A study published in Nature Communications in 2018 found ongoing nicotinamide riboside supplements are well-tolerated and do elevate NAD+ levels in middle-aged and older adults otherwise considered healthy.
- A study published in 2019 in Cell Reports found NR supplementation in older people helped improve NAD+. The same study also found NR supplementation reduced levels of inflammatory cytokines circulating in the systems of participants.
- In 2019 a study published in Scientific Reports found that niagen was generally safe and taking different doses of either 100, 300, or 1000 mg helped increase whole blood NAD+ and other NAD+ metabolites within two weeks.
Are There Any Side Effects?
Thanks to the clinical evidence as well as customer reviews, we do know that Tru Niagen is considered a safe supplement for most people. In studies, people have taken up to 2000 milligrams a day with no significant harmful effects but still speak to your doctor before taking a new supplement.
You might experience mild side effects such as fatigue, stomach discomfort, or indigestion, but these aren’t common.
Unlike a niacin supplement, taking a nicotinamide riboside supplement like Tru Niagen shouldn’t cause flushing either.
Final Thoughts—Do We Recommend Tru Niagen?
In general, NAD+ levels are something that we think will become increasingly relevant in natural health, supplementation, and anti-aging. Understanding how to raise NAD+ levels could represent a new frontier for preventing inflammation and chronic illnesses.
NAD+ fuels all of our cells, yet our levels fall as we age. To combat the signs of aging from the inside out, raising NAD+ levels is likely pivotal, but we don’t necessarily think that an NAD+ supplement is the best way to do that.
Instead, we think an NR supplement like Tru Niagen is a better and more efficient, effective way to raise NAD+ levels, and research supports that’s it’s a well-studied healthy aging nutrient for cellular care.
We think that Tru Niagen is a good supplement for nearly anyone, with your doctor’s approval, because we’re all aging and can all benefit from higher NAD+ levels.
Along with the scientific research to support niagen, we believe the customer reviews for this product are also good indicators that it’s worth the price and something to consider adding to your supplement arsenal potentially.