Ozempic has become a game-changer for many working to manage their blood sugar levels and lose weight.
‘As a GLP-1 receptor agonist, it works by slowing digestion, regulating insulin, and helping control appetite.
While that all sounds great on paper, the reality is that Ozempic can come with some side effects—nausea, fatigue, muscle loss from rapid weight loss, and even nutritional deficiencies.
That’s where the right supplements can make a big difference.
Supplements can help counteract some of Ozempic’s unwanted effects by supporting digestion, energy levels, and overall well-being.
However, not all supplements are created equal, and some work better than others when paired with this medication.
You also have to be mindful of potential drug interactions when choosing the best supplements to take with Ozempic.
In this guide, we’ll break down the best supplements to take with Ozempic for nutritional support and other benefits, why they matter, and how to use them effectively so you can feel your best while on your health journey.
How Ozempic Affects Your Body (And Why Supplements Can Help)
Ozempic works by mimicking a hormone called GLP-1.
This hormone regulates blood sugar and appetite. In addition to injectable versions, oral medications of Ozempic are now available. However, these aren’t the actual brand names—instead, they’re compounded versions of a similar product.
During your weight loss journey, Ozempic slows down digestion, helps the body release insulin more effectively, and reduces cravings—making it an effective tool for managing diabetes and weight loss.
However, these same mechanisms can also lead to some frustrating side effects.
For many people, Ozempic can cause nausea, bloating, and sluggish digestion.
Others may experience low energy, muscle loss from reduced appetite, or even vitamin and mineral deficiencies over time.
Since Ozempic slows down the movement of food through the digestive system, it can impact how well nutrients are absorbed—especially B vitamins, electrolytes, and fat-soluble vitamins like D and K.
This is where supplements come in.
The right ones can help counteract nausea, boost energy, support gut health, and prevent muscle loss—essentially filling in the gaps and making it easier to feel good while taking Ozempic.
In the next sections, we’ll explain exactly which supplements to take with Ozempic, why they work, and how to use them to maintain optimal health. This guide will also discuss potential negative drug interactions.
Best Supplements to Take with Ozempic for Energy & Metabolism
One of the most common complaints people have while taking Ozempic is feeling drained—low energy, sluggishness, and even dizziness.
Since the medication slows digestion and suppresses appetite, it can sometimes lead to dehydration and nutrient deficiencies that impact metabolism and overall energy levels. The good news?
The best supplements to take with Ozempic can help keep your body fueled and functioning properly.
Recommended Supplement Brands for Energy & Metabolism
Electrolytes (Magnesium, Sodium, Potassium)
If you eat less, you probably drink less, too, which can lead to dehydration, a major cause of fatigue and dizziness.
Electrolytes like magnesium, sodium, and potassium help maintain proper hydration levels, support nerve and muscle function, and prevent that lightheaded feeling some people get on Ozempic.
A simple electrolyte powder or mineral-rich foods like avocados, nuts, and leafy greens can help keep your levels in check.
B Vitamins (Especially B12)
Ozempic slows down food’s movement through the body, which can interfere with your nutrient absorption, especially of vitamin B12.
B12 is crucial for energy production, boosting metabolism, and fatigue prevention. If your body isn’t absorbing it well, you might start feeling sluggish or even experience brain fog.
A quality B12 supplement (preferably methylcobalamin for better absorption) can help stabilize energy levels.
If you take diabetes medication like metformin, this can further deplete your B12 levels, which is important to be aware of.
CoQ10
Coenzyme Q10 (CoQ10) is an antioxidant, and it helps your cells produce energy.
Since Ozempic can leave some people feeling more tired than usual, adding CoQ10 to your routine may help combat that sluggishness.
It’s also great for heart health and muscle function, making it a solid addition for anyone experiencing muscle weakness while on the medication.
By incorporating these best supplements with Ozempic, you can help maintain steady energy levels, support your metabolism, and avoid some of the medication’s common side effects.
Next, let’s look at how to keep your digestion running smoothly while taking Ozempic.
Supplements to Support Digestion & Gut Health on Ozempic
Since Ozempic slows down digestion, it’s no surprise that many people experience bloating, nausea, or general stomach discomfort while taking it.
When food sits in your stomach longer than usual, it can throw off gut motility, impact nutrient absorption, and even cause imbalances in gut bacteria.
This is why supplements to take with Ozempic should include options that support digestion and gut health.
Recommended Supplement Brands for Digestion and Gut Health
- UltraFlora Balance Probiotic
- 3-in-1 Prebiotic
- Advanced Digestive Enzymes
- Peppermint Capsules with Ginger and Fennel
Probiotics & Prebiotics
Ozempic can shift the way your gut functions, making it more important than ever to maintain a healthy balance of gut bacteria.
Probiotics introduce beneficial bacteria that can help reduce bloating and keep digestion running smoothly.
Prebiotics, on the other hand, act as food for these good bacteria, helping them thrive and improving overall gut function.
A high-quality probiotic combined with fiber-rich prebiotic foods (like garlic, onions, and bananas) can go a long way in supporting gut health.
Digestive Enzymes
Because Ozempic slows food’s movement through a person’s stomach, some people feel overly full or bloated after eating—even if they don’t eat much.
Digestive enzymes help by breaking down food more efficiently, making it easier for the body to absorb nutrients and reducing bloating and discomfort.
These are especially helpful for people who struggle with nausea or difficulty eating full meals.
Ginger or Peppermint Capsules
If nausea is one of your main complaints with Ozempic, ginger or peppermint supplements can be a lifesaver.
Ginger has long been used to ease nausea and support digestion, while peppermint can help relax the digestive tract and reduce bloating.
Both options are natural, gentle on the stomach, and can make mealtime much more comfortable.
By adding these supplements to take with Ozempic, you can help keep your digestion on track, reduce stomach discomfort, and make the medication much easier to tolerate.
Up next, let’s talk about how to prevent muscle loss while taking Ozempic.
Supplements for Preventing Muscle Loss While on Ozempic
One of the biggest concerns with taking Ozempic—especially for those using it for weight loss—is the loss of lean muscle mass. Since the medication reduces appetite, many people end up eating significantly less, which can lead to a drop in protein intake.
Over time, this can cause muscle breakdown, lower metabolism, and leave you feeling weaker.
The good news?
If you’re wondering what supplements to take with Ozempic to help preserve muscle, there are a few key ones that can make a big difference.
Recommended Supplement Brands to Prevent Muscle Loss
Protein Powder (Whey, Plant-Based, or Collagen)
If you don’t eat enough protein during Ozempic treatment, your body will start removing it from your muscles, leading to loss of strength and even a slower metabolism.
A simple way to prevent this is by adding a protein shake to your daily routine.
Whether you go for whey, plant-based, or collagen protein, the goal is to give your muscles the fuel they need to stay strong.
If you’re struggling with nausea or a lack of appetite, drinking a protein shake can be an easier way to get in protein without having to eat a large meal.
Protein is also good for skin elasticity, which can be affected during periods of rapid weight loss.
Creatine
Creatine is one of the most well-researched supplements for maintaining muscle mass, and it’s especially useful for those taking Ozempic.
It helps your muscles retain water, supports energy production, and improves overall strength. It can also benefit brain function and energy levels, which can sometimes suffer when calorie intake drops.
Even if you’re not lifting weights, creatine can still help preserve lean muscle and keep you feeling strong.
L-Carnitine
L-carnitine has a role in fat metabolism and energy production, making it a great addition for anyone trying to maintain muscle while on Ozempic.
It helps the body use up stored fat for energy, which can be helpful when eating fewer calories.
It’s also been shown to improve workout performance and recovery, so if you’re trying to stay active while on Ozempic, this supplement can be a game-changer.
What Not to Take with Ozempic (Supplements to Be Careful With)
While the right supplements can help support your health while on Ozempic, there are a few that may not mix well with the medication.
Some can interact with Ozempic’s effects on blood sugar, while others may make side effects like nausea or digestive issues even worse.
Here’s what you should be cautious about when considering supplements.
Berberine
Berberine is a popular natural supplement often used to help regulate or lower blood sugar levels.
Still, when combined with Ozempic, it can lower blood sugar too much, leading to dizziness, fatigue, or even hypoglycemia (dangerously low blood sugar).
Since Ozempic is already working to control glucose levels, adding berberine to it can be risky unless a doctor specifically recommends it.
Apple Cider Vinegar
Apple cider vinegar (ACV) is often praised for its potential benefits in blood sugar control and digestion, but there may be negative Ozempic interactions.
Since Ozempic already slows digestion, adding ACV—which can delay stomach emptying even more—might worsen nausea, bloating, and stomach discomfort.
If you love ACV, it’s best to take it in very small amounts and pay attention to how your stomach reacts.
Fat-Soluble Vitamins (A, D, E, K) in High Doses
Since Ozempic slows digestion, it can also impact the absorption of nutrients, especially fat-soluble vitamins (A, D, E, and K).
If you take these in high doses at the wrong time, they may not be absorbed as effectively as they should.
To maximize absorption, the best way to take fat-soluble vitamins is with a meal that contains healthy fats, such as avocado, fatty fish, nuts, or olive oil.
Not all supplements pair well with Ozempic, so it’s important to be mindful of what you’re taking.
How to Choose the Right Supplements for You
Not all supplements are created equal, and it’s important to choose the right ones if you’re going to take them while on Ozempic.
Here’s what to look for when selecting supplements:
Go for High-Quality, Bioavailable Forms
Supplements come in different forms, and some are much easier for your body to absorb than others.
For example:
- Magnesium glycinate is better absorbed than magnesium oxide.
- Methylcobalamin (B12) is more bioavailable than cyanocobalamin.
- CoQ10 in ubiquinol form is better absorbed than ubiquinone
Choosing the right forms ensures that you actually get the benefits of the supplements instead of just passing them through your system.
Time Your Supplements for Better Absorption
Since Ozempic slows digestion, taking certain supplements can make a big difference.
- Fat-soluble vitamins (A, D, E, K): Take them with a meal that has healthy fats.
- Electrolytes: Best taken throughout the day, especially if you’re drinking less water.
- Protein & Creatine: Ideal around workouts or when you’re struggling to hit protein goals.
Talk to Your Doctor If You’re Taking Other Medications
Some supplements can interact with medications, so it’s always a good idea to check with your doctor—especially if you’re managing conditions like diabetes or high blood pressure.
They can help you figure out the safest way to integrate supplements into your routine.
Final Thoughts: Supporting Your Body While Taking Ozempic
Ozempic can be a powerful tool for improving health, but it’s not without its challenges.
From low energy to digestive issues to muscle loss, it’s important to pay attention to how your body responds while on the medication.
Consider taking Ozempic and lab tests simultaneously to monitor how you’re doing overall and see if you need to target any particular deficiencies.
The good news?
A few well-chosen supplements can go a long way in keeping you feeling strong, energized, and balanced.
Whether it’s electrolytes for hydration, protein for muscle maintenance, or probiotics for gut health, small tweaks can make a big difference.
If you’ve been struggling with side effects, don’t ignore them—your body is telling you something!
Try adjusting your supplement routine and see how you feel.
As always, consult a healthcare professional to ensure that your choices align with your overall health goals.
If you have any personal or family history of illnesses, speak with your doctor before you start taking new supplements.
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