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What Is the Best Berberine Supplement?

Last modified on October 20th, 2023

What is the best berberine supplement, who should take this supplement, and how do you compare products?

These are all questions people have about this powerful, pharmaceutical-like supplement.

Below is a guide that answers which berberine supplement is the best and provides everything else to know before you try it.

The Benefits of Berberine

Before going into who sells the best berberine supplement, it’s important to understand how it works and why it’s so popular.

Berberine is a compound naturally occurring in many plants that may help with weight loss, blood sugar control, and other chronic health conditions.

Berberine can potentially help with heart health as well.

The bioactive compound can be extracted from various plants, including a grouping of shrubs known as Berberis.

It’s a bright yellow color, so along with a long history of use in Traditional Chinese Medicine, berberine has also been used as a dye.

There are numerous studies, hundreds, to back up many of the purported berberine benefits.

The way that it works is unique from other supplements.

Berberine activates an enzyme located within cells called AMP-activated protein kinase or AMPK.

The enzyme regulates energy levels and metabolism and is located in cells throughout the body.

There are other ways berberine can affect cellular molecules and may even be able to impact the genes turned on and off.

Blood Sugar Regulation

As far as choosing the best berberine supplement, one of the primary reasons people use it is its effects on blood sugar levels.

Several studies demonstrate berberine’s ability to significantly lower blood sugar in people who have type 2 diabetes, working through multiple mechanisms.

Specifically, berberine may help blood sugar because it can decrease insulin resistance and sugar production in the liver.

Berberine may help with glycolysis, the process where your body breaks down sugars in your cells, and it can slow the rate at which carbs are broken down in your gut.

Weight Loss

As a weight loss supplement, berberine can have significant benefits. Several studies show that berberine supplements helped participants reduce body mass index, belly fat, and body weight.

The plant-based alkaloid might also prevent the molecular growth of fat cells to help lose weight.

Heart Health

Many factors play a role in the increased risk of heart disease, and many of these are improved by berberine. For example, based on a review of more than a dozen studies, as a supplement, it may help lower total cholesterol, including LDL or so-called bad cholesterol. It may increase HDL or good cholesterol and lower blood triglycerides.

Diabetes, obesity, and high blood sugar also contribute to the risk of heart disease, and berberine can potentially improve all of these markers.

Additional Benefits

Other benefits of taking this supplement might include the following:

  • Antioxidant and anti-inflammatory effects
  • Anticancer effects
  • May reduce the risk of infections
  • Could reduce the buildup of fat in the liver
  • May improve symptoms, reducing the risk of death for people with heart failure
  • May help induce autophagy, which can slow the accumulation of damaged cells

What Is the Best Berberine Supplement on the Market?

Below, we detail what we consider the best berberine supplement.

In our decision of which berberine supplement is the best, some of the considerations we kept in mind include:

  • Effectiveness and absorbability
  • Potency
  • Customer reviews
  • Price
  • Brand reputation
  • Accessibility

Renue Liposomal Berberine

Our choice for the best berberine supplement is Renue Liposomal Berberine.

We chose this as our top pick because it’s incredibly bioavailable.

Unfortunately, people often feel like the supplements they take aren’t effective. In reality, they aren’t well-absorbed, and liposomal formulations help with this.

This product uses Advanced Liposomal Technology, which improves the effectiveness of the actual berberine and the amount of it absorbed.

With liposomal supplements, some liposomes serve to encapsulate active ingredients in phospholipids.

This can help protect them from breakdown during the digestive process so that more ingredients reach your bloodstream.

Another reason we feel that this is the best supplement with berberine is that it is third-party tested. The manufacturing facility where it’s made is certified by NSF International and is cGMP certified.

The one downside of this particular supplement is that the price tag is higher than most other brands, but for the liposomal formulation, which is hard to find for this particular supplement, it can be worth it.

How Do You Take It?

You take one pill daily and can take it with or without food.

What’s The Dosage?

The dose for this product is one capsule, with 150 mg of berberine.

You get 90 capsules in a bottle.

What’s The Price?

The price for this product on Amazon is currently $49.95, which is $0.56 per capsule.

What To Know About the Brand

Renue is an excellent supplement brand with a strong reputation for quality and standardizing its products.

The company uses 3rd party testing on all products. Every product goes through stability, purity, and raw material testing, and then the final product is also tested. The raw material testing ensures there aren’t things like heavy metals or mold in the ingredients.

Product assurance testing measures the active ingredient in each capsule or bottle. Stability testing is done periodically on products to ensure minimal degradation.

After the product is finished, it’s sent so the capsules or jars are tested to ensure the amount specified on the bottle is present. Then, with the product assurance test, customers can confirm what they bought has the active ingredients specified.

This is one of my biggest reasons for preferring Renue’s liposomal berberine.

The Downsides

There are downsides to this product, even though it’s one of the few available liposomal formulations. The first is the price.

The second is that each capsule only has 150 mg of berberine. Most studies use 1,000 to 1,500 mg of berberine a day. However, since this is liposomal, you only need a lower dose, and more will be absorbed and used by your body, so that’s not necessarily a dealbreaker.

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Integrative Therapeutics Berberine

Our other pick for who sells the best berberine supplement is Integrative Therapeutics.

First, this brand is fantastic, and second, it has excellent customer reviews on Amazon.

How Do You Take It?

The instructions for this type of supplement indicate that you take one capsule twice or three times daily.

You can take it with or without food.

What’s The Dosage?

The strongest feature of this supplement compared to Renue’s berberine is that each capsule has 500 mg of berberine HCL. If you want a higher dose, even though this isn’t liposomal, it’s a good option.

What’s The Price?

This supplement costs $31.50, which comes out to around $0.53 per capsule.

What To Know About the Brand

I like Integrative Therapeutics products pretty much universally. Clinicians develop them, and again, quality is a big emphasis.

The brand has been around for over 35 years, focusing on potency, accuracy in its ingredients, and purity.

Integrative Therapeutics thoroughly reviews its vendors and tests all its raw materials for potency and purity. They also test the finished products.

The facility where supplements are made has a third-party Good Manufacturing Practices Certification.

The Downsides

The downside with the Integrative Therapeutics product is that it’s not liposomal, but the higher dose in each serving can counteract that negative.

Thorne Berberine

The third and final product I recommend when discussing which berberine supplement is the best is Thorne.

Thorne is one of my favorite supplement companies overall, and their berberine product is excellent because each serving has 1,000 mg of the alkaloid.

There are thousands of customer reviews, most of which are incredibly positive about the product.

This is a great choice if you’re looking for the best berberine supplement for weight loss or PCOS.

There aren’t any fillers or additives unnecessary in Thorne’s supplements, either.

How Do You Take It?

To take the Thorne berberine supplement, take two capsules with or without food.

What’s The Dosage?

The dosage is one gram or 1,000 mg per two capsules and comes from Indian Barberry root extract.

What’s The Price?

This product costs $36.10 for a bottle with 30 capsules, coming out to around $0.60 per capsule.

What To Know About The Brand

Thorne is a major supplement company focusing on personalized and scientifically-driven wellness.

Thorne does enormous amounts of clinical research to ensure they know how every ingredient and supplement works and ensure efficacy and safety.

Thorne thoroughly tests all products, and many are currently being used in clinical trials worldwide.

Thorne works with research organizations, including Cleveland Clinic, Columbia University, Mayo Clinic, Johns Hopkins University, and the National Institutes of Health.

The Downsides

The major downside of this supplement is the price—it’s slightly higher than the other two recommendations on the list.

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Mechanism of Action for Berberine

Berberine is a bioactive compound found in various plants, including goldenseal, barberry, and Chinese goldthread.

It has gained attention for its multiple health benefits, and understanding its mechanism of action is crucial to appreciate its therapeutic potential.

Here’s how berberine works in the body:

AMPK Activation:

One of the key mechanisms through which berberine exerts its effects is by activating AMP-activated protein kinase (AMPK).

AMPK is an enzyme that plays a central role in regulating cellular energy homeostasis.

Berberine stimulates the activation of AMPK, which, in turn, helps enhance energy metabolism. AMPK activation results in several outcomes:

Enhanced Glucose Uptake:

AMPK activation increases glucose uptake into cells, particularly muscle cells, helping lower blood sugar levels.

This is especially beneficial for individuals with insulin resistance and diabetes.

Improved Insulin Sensitivity:

Berberine enhances insulin sensitivity, making the body’s cells more responsive to insulin’s effects, which is crucial for blood sugar regulation.

Increased Fat Oxidation:

AMPK activation promotes the oxidation of fatty acids, leading to improved fat metabolism. This results in reduced fat storage and can aid in weight management.

Inhibition of Inflammatory Pathways:

Berberine has anti-inflammatory properties and can inhibit various pro-inflammatory pathways. This includes the suppression of nuclear factor-kappa B (NF-κB), a transcription factor that regulates many genes involved in inflammation.

By reducing inflammation, berberine may help alleviate symptoms of inflammatory conditions.

Gut Microbiota Modulation:

Berberine can positively impact the composition of the gut microbiota.

It promotes the growth of beneficial bacteria and inhibits the growth of harmful microbes.

A balanced gut microbiome is essential for digestion, nutrient absorption, and overall health.

Regulation of Lipid Metabolism:

Berberine influences lipid metabolism by decreasing the production of cholesterol in the liver and increasing the clearance of cholesterol from the blood. This contributes to improved lipid profiles and heart health.

Potential Effects on Gene Expression:

Berberine has the ability to influence the expression of various genes related to metabolism and inflammation.

By modifying gene expression, it can positively impact multiple biological processes.

How Berberine Modifies Gene Expression

Berberine, a bioactive compound found in several plant sources, is known for its wide range of health benefits, including its ability to modify gene expression. This process is critical in regulating various cellular functions and influencing the body’s response to different stimuli. 

Regulation of Transcription Factors:

Berberine can influence the activity of transcription factors.

Transcription factors are proteins that bind to specific regions of DNA and control the transcription of genes into RNA.

By altering the activity of these transcription factors, berberine can impact the expression of numerous genes.


Epigenetic Modifications:

Berberine can influence epigenetic modifications, which are changes to the structure of DNA or the proteins that interact with DNA without altering the underlying genetic code.

Epigenetic modifications can turn genes on or off. Berberine has been shown to affect DNA methylation and histone acetylation, two key epigenetic mechanisms that control gene expression.

Regulation of Inflammatory Genes:

Berberine’s anti-inflammatory properties are linked to its ability to modify gene expression. It can inhibit the expression of genes that promote inflammation, such as those regulated by the transcription factor NF-κB.

By reducing the activity of these genes, berberine helps mitigate inflammation throughout the body.

Influence on Lipid Metabolism Genes:

Berberine can affect the expression of genes involved in lipid metabolism.

It reduces the production of cholesterol in the liver and increases the clearance of cholesterol from the bloodstream.

This leads to improved lipid profiles and cardiovascular health.

Potential Effects on Gene Expression in Cancer:

Some research suggests that berberine may modify the expression of genes related to cancer.

It can inhibit the expression of genes associated with cancer cell growth, angiogenesis, and metastasis, potentially playing a role in cancer prevention and treatment.

It’s important to note that while berberine has the ability to modify gene expression, its effects are often context-dependent and can vary based on individual factors, including genetics and the specific genes involved.

The dosage and duration of berberine supplementation also play a significant role in achieving desired outcomes. If considering berberine for a specific health condition or goal, it’s advisable to consult with a healthcare professional for personalized guidance.

Berberine’s Similarities to Prescription Drugs: A Natural Approach to Health

Berberine, a natural compound derived from various plants, shares striking similarities with certain prescription drugs in how it affects the body’s physiology.

This natural alternative operates in ways that often mirror pharmaceuticals, providing valuable health benefits.

Here’s how berberine works in a manner comparable to some prescription drugs:

Blood Sugar Regulation:

  • Similarity: Berberine has been likened to metformin, a commonly prescribed diabetes medication. It effectively regulates blood sugar levels by enhancing insulin sensitivity, improving glucose uptake, and reducing glucose production in the liver.
  • Natural Approach: Berberine’s natural origin makes it an attractive option for individuals with diabetes or those at risk of the condition. It provides a holistic approach to blood sugar management, with minimal side effects compared to some pharmaceuticals.

Cholesterol Management:

  • Similarity: Berberine’s cholesterol-lowering effects are akin to statin drugs. It reduces levels of low-density lipoprotein (LDL) or “bad” cholesterol while increasing high-density lipoprotein (HDL) or “good” cholesterol.
  • Natural Approach: Berberine offers a natural way to improve lipid profiles, supporting heart health with fewer potential side effects than some prescription medications.

Anti-Inflammatory Action:

  • Similarity: Berberine possesses anti-inflammatory properties comparable to nonsteroidal anti-inflammatory drugs (NSAIDs). It can inhibit inflammatory pathways and reduce inflammation throughout the body.
  • Natural Approach: Berberine provides a safer alternative for individuals seeking to manage chronic inflammation without the side effects commonly associated with NSAIDs.

Weight Management:

  • Similarity: Berberine can aid in weight management similar to pharmaceutical weight loss agents. It influences metabolism, promotes fat oxidation, and reduces fat storage.
  • Natural Approach: Berberine’s natural origin is appealing for those looking to control their weight without the potential side effects of weight loss drugs.

Antimicrobial Effects:

  • Similarity: Berberine’s antimicrobial properties are comparable to antibiotics. It can inhibit the growth and replication of various microorganisms, including bacteria, viruses, and fungi.
  • Natural Approach: Berberine’s broad-spectrum antimicrobial action can be a valuable natural remedy for infections while potentially reducing the risk of antibiotic resistance.

Gastrointestinal Health:

  • Similarity: Berberine’s role in improving gastrointestinal conditions is akin to certain prescription medications. It can alleviate symptoms of irritable bowel syndrome (IBS) and diarrhea.
  • Natural Approach: Berberine offers a more natural option for those seeking digestive relief, with fewer potential side effects compared to some prescription drugs.

Bioavailability and Absorbability of Berberine: Maximizing Effectiveness

Berberine, a potent natural compound with various health benefits, has some challenges regarding its bioavailability and absorbability.

Bioavailability refers to the proportion of a substance that enters the bloodstream when introduced to the body, while absorbability relates to the ability of the body to take in and utilize a substance effectively.

To maximize the effectiveness of berberine, it’s essential to address these factors and take steps to enhance its bioavailability and absorbability.

Challenges with Berberine:

  • Poor Oral Bioavailability: Berberine has limited oral bioavailability, meaning that when ingested in supplement form, a significant portion is poorly absorbed by the digestive system and eliminated before reaching systemic circulation.
  • Low Absorbability: Berberine’s absorbability can be hindered by factors such as low water solubility and a quick passage through the gut.

Strategies to Improve Bioavailability and Absorbability:

  1. Liposomal Formulations: Liposomal berberine is encapsulated in lipid (fat) molecules, which enhances its solubility and absorption. This approach can significantly improve bioavailability.

  2. Piperine (Black Pepper Extract): Combining berberine with piperine can enhance its absorption. Piperine inhibits enzymes that break down berberine, allowing more of it to enter the bloodstream.

  3. Microencapsulation: Microencapsulated berberine is enveloped in protective coatings, which can slow its release and improve its journey through the digestive system, thereby enhancing its absorption.

  4. Sustained-Release Formulations: Sustained-release berberine supplements are designed to release the compound gradually, promoting better absorption and prolonged effectiveness.

  5. Combination with Other Nutrients: Berberine is often combined with other compounds, such as quercetin or curcumin, which can have synergistic effects on absorption and bioavailability.

  6. Fasting or Empty Stomach: Taking berberine on an empty stomach may enhance its absorption as it won’t compete with food for digestion and absorption.

  7. Dosage Splitting: Dividing the daily dose of berberine into multiple smaller doses can help maintain a higher concentration of the compound in the bloodstream.

  8. Cooperative Use of Probiotics: Berberine can alter the gut microbiome, which, in turn, can influence its absorbability. Taking probiotics alongside berberine may help maintain a balanced gut microbiome and optimize its effects.

  9. Healthy Fat Intake: Consuming healthy fats alongside berberine can improve its solubility and absorption.

  10. Avoid Calcium Supplements: Calcium supplements can interfere with berberine’s absorption, so it’s advisable to take them at separate times.

A Berberine Phytosome is a specialized form of berberine, a bioactive compound derived from various plant sources like goldenseal, barberry, and Chinese goldthread. In a Berberine Phytosome, berberine is combined with phospholipids to improve its bioavailability and absorption. Phospholipids are a class of lipids that are essential components of cell membranes, and they can facilitate the absorption of certain compounds in the body.

The term “phytosome” is used to describe the complex formed when a plant-derived compound like berberine is bound to phospholipids. This process is known as phytosome technology, and it enhances the compound’s ability to be absorbed by the digestive system.

Here’s why Berberine Phytosomes are beneficial:

  1. Improved Bioavailability: Berberine, when taken in its standard form, has limited bioavailability, meaning that a significant portion may not be effectively absorbed into the bloodstream. Berberine Phytosomes, however, have increased bioavailability, which means more of the compound can reach systemic circulation, making it more effective.

  2. Enhanced Absorption: The combination of berberine with phospholipids enhances its absorption through the intestinal wall. This allows for a higher percentage of the berberine to enter the bloodstream and exert its therapeutic effects.

  3. Gentler on the Stomach: Berberine is known to sometimes cause stomach discomfort or gastrointestinal side effects in some people. Berberine Phytosomes may be gentler on the stomach for some individuals due to improved absorption.

  4. Sustained Effects: Berberine Phytosomes can have a more sustained release profile, meaning the effects of berberine are spread out over time. This can reduce the frequency of dosing, which may be more convenient for some users.

Comparing Berberine Supplements: Selecting the Most Effective Option

Berberine supplements have gained popularity due to their potential health benefits, but not all supplements are created equal.

When choosing a berberine supplement, it’s important to consider various factors to ensure that you’re getting the most effective and safe option.

Here’s a guide on how to compare berberine supplements:

Purity and Quality:

Look for berberine supplements that are pure and high-quality.

Ensure that the product is free from contaminants, fillers, and additives.

This information is often found on the product label or the manufacturer’s website.


Consider the formulation of the supplement.

While berberine is available in various forms (HCl, sulfate, and more), berberine HCl is the most commonly used and well-researched form. It is known for its effectiveness and bioavailability.


Check the dosage of berberine per serving. An effective dose typically ranges from 500 mg to 1500 mg per day.

Ensure that the supplement provides an appropriate dosage for your specific health goals.

Bioavailability Enhancement:

Look for berberine supplements that incorporate bioavailability-enhancing techniques, such as liposomal delivery, piperine (black pepper extract), or microencapsulation.

These methods can improve the absorption of berberine.

Third-Party Testing:

Choose supplements that undergo third-party testing for quality and purity.

This ensures that the product meets established standards and is free from contaminants.

Sustained-Release vs. Immediate Release:

Consider whether you prefer a sustained-release or immediate-release formulation.

Sustained-release supplements release berberine gradually over time, potentially allowing for fewer daily doses. Immediate-release supplements release the compound more rapidly, which may require more frequent dosing.

Combination Supplements:

Some berberine supplements combine berberine with other beneficial compounds, such as quercetin, curcumin, or cinnamon extract.

These combinations can offer synergistic effects and provide additional health benefits.

Reputation and Brand:

Research the reputation and trustworthiness of the brand or manufacturer.

Look for brands with a history of producing high-quality supplements and positive customer reviews.

Cost and Value:

Compare prices and consider the value provided by the supplement.

Assess the cost per serving and dosage strength to determine if it aligns with your budget and needs.

Health Goals:

Select a berberine supplement that aligns with your specific health goals.

Berberine is often used for blood sugar regulation, cholesterol management, weight management, and more.

The supplement’s formulation and dosage should match your objectives.

Consult a Healthcare Professional:

If you have specific health concerns or are taking medications, consult with a healthcare professional before starting a berberine supplement.

They can provide guidance on the most suitable product for your situation.

Berberine vs. Dihydroberberine: A Comparison

Berberine and dihydroberberine are two closely related compounds that share similarities but have some crucial differences.

They both have potential health benefits and are often used as dietary supplements. Here’s a comparison of berberine and dihydroberberine:

Chemical Structure:

  • Berberine: Berberine is an alkaloid compound found in various plants, including goldenseal, barberry, and Chinese goldthread. Its chemical structure consists of three aromatic rings and a quaternary ammonium group.
  • Dihydroberberine: Dihydroberberine is a derivative of berberine that has undergone a reduction process, converting one of its aromatic rings to a saturated ring. This alteration results in a dihydroberberine molecule.


  • Berberine: Berberine has relatively low bioavailability, meaning that a significant portion of it may not be effectively absorbed by the body when taken orally. This can limit its effectiveness.
  • Dihydroberberine: Dihydroberberine is known for its significantly improved bioavailability compared to berberine. The reduction in its chemical structure enhances its absorption, making it a more efficient option.

Effect on AMPK:

  • Berberine: Berberine is recognized for its ability to activate AMP-activated protein kinase (AMPK), an enzyme that plays a key role in energy metabolism, glucose regulation, and fat oxidation.
  • Dihydroberberine: Dihydroberberine also activates AMPK, similar to berberine, and can have similar effects on metabolism and energy balance.

Health Benefits:

  • Berberine: Berberine is commonly used to support blood sugar regulation, cholesterol management, weight loss, and various other health goals. Its benefits are well-documented in scientific research.
  • Dihydroberberine: Dihydroberberine is often marketed as a more potent and effective form of berberine due to its improved bioavailability. It can provide similar health benefits as berberine, with the advantage of requiring lower doses.


  • Berberine: Typical dosages of berberine range from 500 mg to 1500 mg per day, depending on the intended use.
  • Dihydroberberine: Due to its enhanced bioavailability, dihydroberberine is often used in smaller doses, usually in the range of 50-150 mg per day.

Tolerance and Side Effects:

  • Both berberine and dihydroberberine are generally well-tolerated by most individuals. However, some people may experience gastrointestinal side effects, such as stomach discomfort or diarrhea, especially at higher doses.


  • Berberine supplements, particularly berberine HCl (hydrochloride), are widely available and come from various plant sources.
  • Dihydroberberine supplements are less common but can be found from select manufacturers and suppliers.

The Best Supplements to Take with Berberine

Several supplements and compounds can synergize with berberine, enhancing its health benefits and overall effectiveness.

These synergistic interactions can lead to more comprehensive support for various health goals, such as blood sugar regulation, cholesterol management, and weight loss.

Here are some supplements and compounds that work well with berberine:


Curcumin, the active component of turmeric, has anti-inflammatory and antioxidant properties.

When combined with berberine, it can enhance the overall anti-inflammatory effects and help manage inflammation-related conditions.


Quercetin is a flavonoid with antioxidant properties.

It can improve the bioavailability of berberine and enhance its absorption.

Together, they can provide better support for blood sugar control.

Cinnamon Extract:

Cinnamon contains compounds that mimic insulin’s effects and improve insulin sensitivity.

When taken alongside berberine, it can provide additional support for blood sugar regulation.

Alpha-Lipoic Acid (ALA):

ALA is an antioxidant that has shown promise in supporting blood sugar control and reducing peripheral neuropathy symptoms.

Combining ALA with berberine may offer enhanced benefits for those with diabetes or metabolic syndrome.

Milk Thistle:

Milk thistle contains silymarin, a compound known for its liver-protective properties.

When combined with berberine, it can help improve liver health and support the metabolism of both compounds.


Resveratrol is an antioxidant found in red grapes and red wine. It can enhance the effects of berberine on metabolic health and may aid in weight management.


L-carnitine is an amino acid that plays a role in fat metabolism. W

hen taken with berberine, it can help improve the oxidation of fatty acids, supporting weight loss and fat loss efforts.

Omega-3 Fatty Acids:

Omega-3 fatty acids found in fish oil can work synergistically with berberine to support cardiovascular health and reduce inflammation.


Magnesium is vital for various physiological processes, including glucose regulation.

When combined with berberine, it can enhance the overall effectiveness in supporting blood sugar control.

Green Tea Extract:

Green tea contains catechins, particularly epigallocatechin gallate (EGCG), which can enhance berberine’s metabolism-boosting and weight-loss effects.


Probiotics help maintain a healthy gut microbiome, which can improve the bioavailability of berberine and its effectiveness in metabolic support.

What to Avoid When Taking Berberine: A Guide to Safe Use

Berberine is a natural compound with numerous health benefits, but it should be used with care like any supplement. To ensure its safe and effective use, it’s important to be aware of what to avoid when taking berberine.

Here are some key considerations:


Avoid excessive alcohol consumption:

Berberine can interact with alcohol and may potentially increase the risk of side effects. It’s advisable to limit alcohol intake or avoid it altogether when taking berberine.

Medication Interactions:

Consult a healthcare professional: Berberine can interact with various medications, including those for diabetes, blood pressure, and cholesterol. It’s crucial to consult with a healthcare provider before taking berberine, especially if you are on medication. Your doctor can help you determine the right dosage and monitor your progress.


Be cautious with antibiotics: Berberine has natural antibiotic properties, which can be beneficial for some health conditions. However, it’s important to be cautious when using it alongside prescription antibiotics, as it may affect their efficacy. Consult your healthcare provider if you are taking antibiotics and considering berberine supplementation.

Diarrhea Medications:

Berberine may exacerbate diarrhea: In some individuals, berberine can lead to gastrointestinal side effects, including diarrhea. Avoid taking berberine along with medications that treat diarrhea, as it may counteract their effects.

High-Fat Meals:

Limit high-fat meals when taking berberine: Some studies suggest that berberine’s absorption may be reduced when consumed with high-fat meals. To maximize its effectiveness, taking berberine on an empty stomach or with a light, low-fat meal is advisable.

Excessive Caffeine:

Moderate caffeine intake: High caffeine consumption can potentially lead to increased nervousness, anxiety, or jitteriness when combined with berberine. It’s best to moderate caffeine intake or consider alternatives if you are sensitive to caffeine’s effects.

Extended Usage Without Breaks:

Cycling berberine use: While berberine is generally safe for most people, long-term, uninterrupted use may lead to tolerance. Some individuals choose to cycle berberine use, taking it for a specific period and then having a break before resuming. This can help maintain its effectiveness.

Allergic Reactions:

Watch for allergies: Allergies to berberine-containing plants like goldenseal or Oregon grape can occur. If you have a known allergy to these plants, avoid berberine supplementation.

Pregnancy and Lactation:

Avoid during pregnancy and lactation: Limited research is available on the safety of berberine during pregnancy and breastfeeding. It’s best to err on the side of caution and avoid berberine supplementation during these periods.

Underlying Health Conditions:

Consult with a healthcare professional: Individuals with certain medical conditions, such as liver disease, kidney disease, or heart conditions, should consult with a healthcare provider before using berberine. Berberine can affect various systems in the body, so it’s crucial to consider individual health needs and potential interactions.

Final Thoughts

Berberine is arguably one of the most interesting supplements on the market because of its ability to work within the cells of the body, similar to pharmaceutical medications. Our picks for the best berberine supplements above are what we think represent the highest quality, purity, and potency levels, and they’re from some of the best supplement brands in the world.

Our Editorial Process

All of our reviews are completely unbiased. We have an in-depth review and ranking methodology for each of our products. We base our reviews on:

  • Peer-reviewed scientific studies and research
  • Real customer reviews
  • Our own experience using products
  • Price and availability

Whenever possible, we review and rank products that we actually use to provide a better understanding of what you can expect. 

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